The ACMG panel, endorsed by the American College of Medical Genetics and Genomics (ACMG), is a targeted genetic testing approach focusing on specific genes or genomic regions according to ACMG guidelines. It aids in diagnosing genetic disorders, including hereditary conditions with actionable outcomes. These genes are carefully selected based on their potential for actionable results, where early intervention significantly improves prognosis, life expectancy, quality of life, and overall well-being. Early detection, even before symptoms manifest, enables the initiation of prompt multidisciplinary treatment, preventing the progression of diseases. The primary objective is to identify known or expected pathogenic variants in these genes, even if they are unrelated to the primary medical reason for testing. This approach is especially beneficial in exome and genome sequencing, contributing to comprehensive genetic assessments.